CILP CLIA Kit for Human(Homo sapiens) | EIAab.comCILP CLIA Kit for Human(Homo sapiens)

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Index > Protein center > CILP(Gene name) > Human

CILP (Gene name),

Cartilage intermediate layer protein 1 (Protein name ), CILP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CILP(UNQ602/PRO1188);

Protein name:

Cartilage intermediate layer protein 1(CILP-1);

Alternative:

Cartilage intermediate-layer protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. Interacts with TGFB1.

Function:

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.

Subcellular Location:

Secreted extracellular space extracellular matrix

Protein Attributes:

Sequence length:

1184

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1184:

PSRRQQRASR | GGQRQGGVVA | SLRFPRVAQQ | PLIN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O75339

Pfam:

PF07679

KEGG:

hsa:8483

UniGene:

Hs.442180

SMR:

O75339

STRING:

9606.ENSP00000261883

MIM:

603489

Pfam:

PF13330

Uniprot:

O75339

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ELISA Kit for Human CILP-1

Cat.:

E1182m

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96T

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ELISA Kit for Human CILP-1

Cat.:

E1182h

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96T

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ELISA Kit for Human CILP-1

Cat.:

E1182p

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Packing:

96T

CLIA Kit for Human CILP-1

Cat.:

U1182m

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Packing:

96T

CLIA Kit for Human CILP-1

Cat.:

U1182p

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MSDS:

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Packing:

96T

CLIA Kit for Human CILP-1

Cat.:

U1182h

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Packing:

96T

Polyclonal Antibody for Human CILP-1

Cat.:

P1182Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human CILP-1

Cat.:

P1182Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human CILP-1

Protein for Human CILP-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase."
Lorenzo P. , Neame P. , Sommarin Y. , Heinegaerd D.
J. Biol. Chem.273:23469-23475(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 39-58; 282-291; 301-317; 332-338; 341-356; 361-365; 524-547; 575-594; 680-690 AND 698-707;GLYCOSYLATION AT ASN-346;PROTEOLYTIC PROCESSING;TISSUE SPECIFICITY;VARIANTS LEU-59; THR-395; GLU-575; ARG-979 AND SER-1166
tissue: Articular cartilage.
2.

"Genomic organization, mapping, and polymorphisms of the gene encoding human cartilage intermediate layer protein (CILP)."
Nakamura I. , Okawa A. , Ikegawa S. , Takaoka K. , Nakamura Y.
J. Hum. Genet.44:203-205(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-59; PHE-327; THR-395; GLU-575; VAL-895; ARG-979; ASN-1101; SER-1166 AND ALA-1168
3.

"The human CILP gene: exon/intron organization and chromosomal mapping."
Lorenzo P. , Aman P. , Sommarin Y. , Heinegaerd D.
Matrix Biol.18:445-454(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-59; THR-395; GLU-575; ARG-979 AND SER-1166
4.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS THR-395; GLU-575 AND ARG-979
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS THR-395; GLU-575; ARG-979 AND SER-1166
tissue: Testis.
6.

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C. , Garber M. , Sharpe T. , Young S.K. , Rowen L. , O'Neill K. , Whittaker C.A. , Kamal M. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Kodira C.D. , Madan A. , Qin S. , Yang X. , Abbasi N. , Abouelleil A. , more...
Nature440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS GLU-575; ARG-979 AND SER-1166
tissue: Ovary.
8.

"A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age."
Lorenzo P. , Bayliss M.T. , Heinegaerd D.
J. Biol. Chem.273:23463-23468(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;GLYCOSYLATION;TISSUE SPECIFICITY
9.

"Up-regulated expression of cartilage intermediate-layer protein and ANK in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease."
Hirose J. , Ryan L.M. , Masuda I.
Arthritis Rheum.46:3218-3229(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
10.

"Implication of cartilage intermediate layer protein in cartilage destruction in subsets of patients with osteoarthritis and rheumatoid arthritis."
Tsuruha J. , Masuko-Hongo K. , Kato T. , Sakata M. , Nakamura H. , Nishioka K.
Arthritis Rheum.44:838-845(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS
11.

"One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist."
Johnson K. , Farley D. , Hu S.-I. , Terkeltaub R.
Arthritis Rheum.48:1302-1314(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Characterisation of cartilage intermediate layer protein (CILP)-induced arthropathy in mice."
Yao Z. , Nakamura H. , Masuko-Hongo K. , Suzuki-Kurokawa M. , Nishioka K. , Kato T.
Ann. Rheum. Dis.63:252-258(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IMMUNISATION
13.

"The prevalence of autoantibodies against cartilage intermediate layer protein, YKL-39, osteopontin, and cyclic citrullinated peptide in patients with early-stage knee osteoarthritis: evidence of a variety of autoimmune processes."
Du H. , Masuko-Hongo K. , Nakamura H. , Xiang Y. , Bao C.-D. , Wang X.-D. , Chen S.-L. , Nishioka K. , Kato T.
Rheumatol. Int.26:35-41(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN OSTEOARTHRITIS
14.

"A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease."
Seki S. , Kawaguchi Y. , Chiba K. , Mikami Y. , Kizawa H. , Oya T. , Mio F. , Mori M. , Miyamoto Y. , Masuda I. , Tsunoda T. , Kamata M. , Kubo T. , Toyama Y. , Kimura T. , Nakamura Y. , Ikegawa S.
Nat. Genet.37:607-612(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH TGFB1;ASSOCIATION OF VARIANT THR-395 WITH SUSCEPTIBILITY TO INTERVERTEBRAL DISK DISEASE
15.

"Diagnostic exome sequencing in persons with severe intellectual disability."
de Ligt J. , Willemsen M.H. , van Bon B.W. , Kleefstra T. , Yntema H.G. , Kroes T. , Vulto-van Silfhout A.T. , Koolen D.A. , de Vries P. , Gilissen C. , del Rosario M. , Hoischen A. , Scheffer H. , de Vries B.B. , Brunner H.G. , Veltman J.A. , Vissers L.E.
N. Engl. J. Med.367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-495 AND THR-1032

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